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nfkbia.L NFKB inhibitor alpha L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446833, updated on 4-Nov-2024

Summary

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Official Symbol
nfkbia.L
Official Full Name
NFKB inhibitor alpha L homeolog
Primary source
Xenbase:XB-GENE-866028
Locus tag
XELAEV_18039957mg
See related
EnsemblRapid:ENSXLAG00005034593 AllianceGenome:Xenbase:XB-GENE-866028
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nfkbia
Summary
Predicted to enable NF-kappaB binding activity. Predicted to act upstream of or within cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; and toll-like receptor 4 signaling pathway. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See nfkbia.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (101702923..101706353, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (87013501..87016931, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene protein only RNase P catalytic subunit L homeolog Neighboring gene proteasome subunit alpha 6 L homeolog Neighboring gene major histocompatibility complex, class 1, UC alpha chain L homeolog Neighboring gene serine/arginine-rich splicing factor 5 alpha L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. Arenzana-Seisdedos F, et al. J Cell Sci, 1997 Feb. PMID 9057089
  2. zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. Diaz-Meco MT, et al. EMBO J, 1994 Jun 15. PMID 8026469, Free PMC Article
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC80640

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoplasmic sequestering of NF-kappaB IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NFKB inhibitor alpha L homeolog
Names
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093529.1 → NP_001086998.1  NFKB inhibitor alpha L homeolog

    See identical proteins and their annotated locations for NP_001086998.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077876
    UniProtKB/TrEMBL
    A0A974C9S8, Q6DCW3
    Related
    ENSXLAP00005103444.1, ENSXLAT00005105449.1
    Conserved Domains (5) summary
    COG0666
    Location:19 → 169
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:108 → 239
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:118 → 214
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:204 → 258
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:146 → 182
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    101702923..101706353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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