xpr1.L xenotropic and polytropic retrovirus receptor 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: xpr1.L
Official Full Name: xenotropic and polytropic retrovirus receptor 1 L homeolog
Primary source: Xenbase:XB-GENE-1015951
Locus tag: XELAEV_18023277mg
See related: EnsemblRapid:ENSXLAG00005030983 AllianceGenome:Xenbase:XB-GENE-1015951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: xpr1
Summary: Predicted to enable efflux transmembrane transporter activity; inositol hexakisphosphate binding activity; and phosphate transmembrane transporter activity. Predicted to act upstream of or within intracellular phosphate ion homeostasis and phosphate ion transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (96664682..96746457, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (91397114..91479164, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter.
Title: XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to phosphate starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular phosphate ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphate ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphate ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: xenotropic and polytropic retrovirus receptor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093461.1 → NP_001086930.1 xenotropic and polytropic retrovirus receptor 1 homolog

See identical proteins and their annotated locations for NP_001086930.1

Status: PROVISIONAL

Source sequence(s)

BC077785

UniProtKB/Swiss-Prot

Q6DD44

UniProtKB/TrEMBL

A0A974HNX8

Related

ENSXLAP00005093295.1, ENSXLAT00005094979.1

Conserved Domains (3) summary

cd14477
Location:2 → 165

SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins

pfam03105
Location:3 → 169

SPX; SPX domain

pfam03124
Location:269 → 613

EXS; EXS family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

96664682..96746457 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)