pfkm.S phosphofructokinase, muscle S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pfkm.S
Official Full Name: phosphofructokinase, muscle S homeolog
Primary source: Xenbase:XB-GENE-1000687
Locus tag: XELAEV_18015986mg
See related: EnsemblRapid:ENSXLAG00005026676 AllianceGenome:Xenbase:XB-GENE-1000687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pfk; pfkm
Summary: Predicted to enable several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Predicted to act upstream of or within several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm and membrane. Predicted to be part of 6-phosphofructokinase complex. Is expressed in respiratory system. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (135048439..135095744, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (126041447..126074884, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 6-phosphofructokinase activity	IEA Inferred from Electronic Annotation more info
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fructose-6-phosphate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within canonical glycolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fructose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 6-phosphofructokinase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphofructokinase, muscle S homeolog

NP_001086921.1

EC 2.7.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093452.1 → NP_001086921.1 phosphofructokinase, muscle S homeolog

See identical proteins and their annotated locations for NP_001086921.1

Status: PROVISIONAL

Source sequence(s)

BC077756

UniProtKB/TrEMBL

A0A974DJ65, Q6DD69

Related

ENSXLAP00005080071.1, ENSXLAT00005081664.1

Conserved Domains (2) summary

cd00764
Location:42 → 802

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

TIGR02478
Location:45 → 784

6PF1K_euk; 6-phosphofructokinase, eukaryotic type

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

135048439..135095744 complement

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GenBank, FASTA, Sequence Viewer (Graphics)