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ilkap.L ILK associated serine/threonine phosphatase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446725, updated on 4-Nov-2024

Summary

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Official Symbol
ilkap.L
Official Full Name
ILK associated serine/threonine phosphatase L homeolog
Primary source
Xenbase:XB-GENE-1000329
Locus tag
XELAEV_18027835mg
See related
EnsemblRapid:ENSXLAG00005015862 AllianceGenome:Xenbase:XB-GENE-1000329
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ilkap
Summary
Predicted to enable kinase activity; metal ion binding activity; and protein serine/threonine phosphatase activity. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; peptidyl-threonine dephosphorylation; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleus. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ilkap.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (135677793..135689531)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (124598180..124610663)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene allantoinase, mitochondrial-like L homeolog Neighboring gene kinesin family member 1A L homeolog Neighboring gene tRNA methyltransferase 10A L homeolog Neighboring gene erythroferrone L homeolog Neighboring gene kelch like family member 30 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC84595

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-threonine dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ILK associated serine/threonine phosphatase L homeolog; integrin-linked kinase-associated serine/threonine phosphatase 2C
XP_018117443.1
XP_018117444.1
XP_018117445.1
XP_018117446.1
XP_041419367.1
XP_041419368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    135677793..135689531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018261954.2 → XP_018117443.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

    UniProtKB/TrEMBL
    A0A8J0V9S0

  2. XM_018261955.2 → XP_018117444.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

    UniProtKB/TrEMBL
    A0A8J0V9S0

  3. XM_041563433.1 → XP_041419367.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3

    UniProtKB/TrEMBL
    A0A974CX15, Q6AZM6
    Conserved Domains (1) summary
    cd00143
    Location:61 → 342
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  4. XM_018261957.2 → XP_018117446.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X4

    UniProtKB/TrEMBL
    A0A8J0V5A5

  5. XM_018261956.2 → XP_018117445.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

    UniProtKB/TrEMBL
    A0A8J0V960
    Related
    ENSXLAP00005046659.1, ENSXLAT00005047763.1

  6. XM_041563434.1 → XP_041419368.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X5

    UniProtKB/TrEMBL
    A0A8J1KRI5
    Conserved Domains (1) summary
    cd00143
    Location:49 → 330
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001093421.1: Suppressed sequence

    Description
    NM_001093421.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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