wipi1.L WD repeat domain, phosphoinositide interacting 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wipi1.L
Official Full Name: WD repeat domain, phosphoinositide interacting 1 L homeolog
Primary source: Xenbase:XB-GENE-17333101
Locus tag: XELAEV_18044241mg
See related: EnsemblRapid:ENSXLAG00005018350 AllianceGenome:Xenbase:XB-GENE-17333101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: atg18; wipi49
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to act upstream of or within autophagy of mitochondrion; macroautophagy; and protein lipidation. Predicted to be located in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (53512796..53526006)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (42956427..42969650)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy of mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein lipidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to phagophore assembly site	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat domain, phosphoinositide interacting 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093405.1 → NP_001086874.1 WD repeat domain, phosphoinositide interacting 1 L homeolog

See identical proteins and their annotated locations for NP_001086874.1

Status: PROVISIONAL

Source sequence(s)

BC077590

UniProtKB/TrEMBL

A0A974BUK4, Q6DDH3

Related

ENSXLAP00005054207.1, ENSXLAT00005055381.1

Conserved Domains (3) summary

COG2319
Location:116 → 291

WD40; WD40 repeat [General function prediction only]

sd00039
Location:142 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:84 → 258

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

53512796..53526006

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041575661.1 → XP_041431595.1 WD repeat domain, phosphoinositide interacting 1 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8EV03, A0A974BUK4, A0A974BYE8

Related

ENSXLAP00005054218.1, ENSXLAT00005055392.1

Conserved Domains (2) summary

sd00039
Location:142 → 180

7WD40; WD40 repeat [structural motif]

cl29593
Location:84 → 258

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_041575662.1 → XP_041431596.1 WD repeat domain, phosphoinositide interacting 1 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1LR82, A0A974BUK4

Conserved Domains (2) summary

sd00039
Location:114 → 152

7WD40; WD40 repeat [structural motif]

cl29593
Location:56 → 230

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...