dnaaf4.L dynein axonemal assembly factor 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dnaaf4.L
Official Full Name: dynein axonemal assembly factor 4 L homeolog
Primary source: Xenbase:XB-GENE-959584
Locus tag: XELAEV_18018183mg
See related: AllianceGenome:Xenbase:XB-GENE-959584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: EKN1; dnaaf4; dyx1c1; dyx1c1.L
Summary: Predicted to enable nuclear estrogen receptor binding activity. Predicted to act upstream of or within several processes, including axonemal dynein complex assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Located in dynein axonemal particle. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (105944642..105958252)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (90599882..90613586)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner dynein arm assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within outer dynein arm assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	IDA Inferred from Direct Assay more info	PubMed
located_in dynein axonemal particle	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein axonemal assembly factor 4; dynein axonemal assembly factor 4 L homeolog

Names: Dynein assembly factor 4, axonemal; dyslexia susceptibility 1 candidate 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093395.1 → NP_001086864.1 dynein axonemal assembly factor 4

See identical proteins and their annotated locations for NP_001086864.1

Status: PROVISIONAL

Source sequence(s)

BC077575

UniProtKB/Swiss-Prot

Q6AZN0

UniProtKB/TrEMBL

Q5VJS2

Conserved Domains (4) summary

cd06469
Location:10 → 86

p23_DYX1C1_like; p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD ...

TIGR00990
Location:273 → 386

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:280 → 308

TPR; TPR repeat [structural motif]

pfam17380
Location:93 → 261

DUF5401; Family of unknown function (DUF5401)