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usp25.L ubiquitin specific peptidase 25 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446581, updated on 4-Nov-2024

Summary

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Official Symbol
usp25.L
Official Full Name
ubiquitin specific peptidase 25 L homeolog
Primary source
Xenbase:XB-GENE-946526
Locus tag
XELAEV_18011587mg
See related
EnsemblRapid:ENSXLAG00005028602 AllianceGenome:Xenbase:XB-GENE-946526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
usp25
Summary
Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; and regulation of proteasomal protein catabolic process. Orthologous to human USP25 (ubiquitin specific peptidase 25). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See usp25.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
26
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (26218208..26305165)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (26021946..26109168)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor interacting protein 1 L homeolog Neighboring gene posterior protein-like Neighboring gene uncharacterized LOC108707907 Neighboring gene CXADR, Ig-like cell adhesion molecule L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81666

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin specific peptidase 25 L homeolog
Names
ubiquitin specific protease 25
NP_001086746.1
XP_018100613.1
XP_041436954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093277.1 → NP_001086746.1  ubiquitin specific peptidase 25 L homeolog

    See identical proteins and their annotated locations for NP_001086746.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077389
    UniProtKB/TrEMBL
    A0A974DL10, Q6DDW3
    Related
    ENSXLAP00005086453.1, ENSXLAT00005088115.1
    Conserved Domains (3) summary
    cd02665
    Location:169 → 647
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:14 → 59
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    pfam00443
    Location:167 → 404
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    26218208..26305165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018245124.2 → XP_018100613.1  ubiquitin specific peptidase 25 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8HCV2, A0A974DI13, A0A974DL55
    Related
    ENSXLAP00005086002.1, ENSXLAT00005087665.1

  2. XM_041581020.1 → XP_041436954.1  ubiquitin specific peptidase 25 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1M5J4, A0A974DL10
    Related
    ENSXLAP00005086138.1, ENSXLAT00005087798.1
    Conserved Domains (4) summary
    COG5207
    Location:168 → 633
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02665
    Location:169 → 647
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:14 → 59
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cd20486
    Location:791 → 1071
    USP25_C; carboxyl-terminal domain of ubiquitin-specific protease 25 (USP25)
Nucleotide Protein Strain
Heading Accession and Version

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