tsg101.L tumor susceptibility 101 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tsg101.L
Official Full Name: tumor susceptibility 101 L homeolog
Primary source: Xenbase:XB-GENE-6255929
Locus tag: XELAEV_18021659mg
See related: EnsemblRapid:ENSXLAG00005018945 AllianceGenome:Xenbase:XB-GENE-6255929
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tsg10; vps23; tsg101
Summary: Predicted to enable ubiquitin binding activity. Predicted to act upstream of or within endosome to lysosome transport; protein modification process; and protein transport. Predicted to be located in endosome. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (232222..244343, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (238810..243664, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor susceptibility 101 L homeolog

Names: tumor susceptibility gene 101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093267.1 → NP_001086736.1 tumor susceptibility 101 L homeolog

See identical proteins and their annotated locations for NP_001086736.1

Status: PROVISIONAL

Source sequence(s)

BC077372

UniProtKB/TrEMBL

Q6DDX9

Related

ENSXLAP00005055844.1, ENSXLAT00005057073.1

Conserved Domains (1) summary

pfam05743
Location:22 → 139

UEV; UEV domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

232222..244343 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589332.1 → XP_041445266.1 tumor susceptibility 101 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MW83, A0A974CZ95

Conserved Domains (2) summary

COG1579
Location:248 → 355

COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]

cl00154
Location:23 → 154

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
XM_041589331.1 → XP_041445265.1 tumor susceptibility 101 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MW83, A0A974CZ95

Related

ENSXLAP00005055864.1, ENSXLAT00005057093.1

Conserved Domains (2) summary

COG1579
Location:248 → 355

COG1579; Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only]

cl00154
Location:23 → 154

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...