syk.L spleen tyrosine kinase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: syk.L
Official Full Name: spleen tyrosine kinase L homeolog
Primary source: Xenbase:XB-GENE-978187
Locus tag: XELAEV_18006998mg
See related: EnsemblRapid:ENSXLAG00005027650 AllianceGenome:Xenbase:XB-GENE-978187
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: syk
Summary: Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within several processes, including B cell receptor signaling pathway; myeloid cell activation involved in immune response; and positive regulation of lymphocyte activation. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (149544947..149582036)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (136667816..136705156)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil activation involved in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: spleen tyrosine kinase L homeolog; tyrosine-protein kinase SYK

XP_018101865.1

XP_041420680.1

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The following sections contain reference sequences that belong to a specific genome build. Explain

The following Reference Sequences have been suppressed. Explain

NM_001093196.1: Suppressed sequence

Description

NM_001093196.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.