rit1.L Ras-like without CAAX 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rit1.L
Official Full Name: Ras-like without CAAX 1 L homeolog
Primary source: Xenbase:XB-GENE-5777085
Locus tag: XELAEV_18040962mg
See related: EnsemblRapid:ENSXLAG00005004082 AllianceGenome:Xenbase:XB-GENE-5777085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rit1
Summary: Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Predicted to act upstream of or within Ras protein signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (135099189..135108786)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (119811094..119820609)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ras-like without CAAX 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093180.1 → NP_001086649.1 Ras-like without CAAX 1 L homeolog

See identical proteins and their annotated locations for NP_001086649.1

Status: PROVISIONAL

Source sequence(s)

BC077235

UniProtKB/TrEMBL

A0A974H9E1, Q6AZU5

Related

ENSXLAP00005012212.1, ENSXLAT00005012390.1

Conserved Domains (2) summary

smart00010
Location:16 → 181

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04141
Location:16 → 187

Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)