hspb6.L heat shock protein family B (small) member 6 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hspb6.L
Official Full Name: heat shock protein family B (small) member 6 L homeolog
Primary source: Xenbase:XB-GENE-876275
Locus tag: XELAEV_18036463mg
See related: EnsemblRapid:ENSXLAG00005015389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: HSP20; hspb6
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 7L

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (135166124..135169338, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (122273190..122276404)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSPB6 cDNA encodes a 168 aa protein that contains an alpha-crystallin domain, a polar C-terminal extension and some possible phosphorylation sites. HSPB6 shares 94% identity with a X. tropicalis HSPB6, 65% with turtle, 59% with humans, 49% with zebrafish and only 50% and 43% with X. laevis HSPB1 and HSP30C, respectively.
Title: Expression and localization of the Xenopus laevis small heat shock protein, HSPB6 (HSP20), in A6 kidney epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein refolding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock protein family B (small) member 6 L homeolog

Names: heat shock protein, alpha-crystallin-related, B6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093010.1 → NP_001086479.1 heat shock protein family B (small) member 6 L homeolog

See identical proteins and their annotated locations for NP_001086479.1

Status: PROVISIONAL

Source sequence(s)

BC075197

UniProtKB/TrEMBL

A0A974HDH6, Q6DJI2

Related

ENSXLAP00005045095.1, ENSXLAT00005046194.1

Conserved Domains (3) summary

cd06478
Location:68 → 149

ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...

COG0071
Location:35 → 163

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]

pfam00525
Location:1 → 53

Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

135166124..135169338 complement

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GenBank, FASTA, Sequence Viewer (Graphics)