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Nlrp4e NLR family, pyrin domain containing 4E [ Mus musculus (house mouse) ]

Gene ID: 446099, updated on 15-Oct-2024

Summary

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Official Symbol
Nlrp4eprovided by MGI
Official Full Name
NLR family, pyrin domain containing 4Eprovided by MGI
Primary source
MGI:MGI:3056600
See related
Ensembl:ENSMUSG00000045693 AllianceGenome:MGI:3056600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nlrp4; Nalp4e; Nalp-epsilon; 4930406H16Rik
Summary
Predicted to enable ATP binding activity. Predicted to act upstream of or within inflammatory response. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Nlrp4e in Genome Data Viewer
Location:
7 A3; 7 10.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23000617..23061702)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (23301192..23362277)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6902 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene keratin 8, pseudogene Neighboring gene NLR family, pyrin domain containing 5 Neighboring gene coiled-coil domain containing 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental expression and possible functional roles of mouse Nlrp4e in preimplantation embryos. Chang BH, et al. In Vitro Cell Dev Biol Anim, 2013 Aug. PMID 23708922
  2. Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice. DeSantis DA, et al. Mediators Inflamm, 2013. PMID 24453428, Free PMC Article
  3. USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome. Lin M, et al. Mol Cell, 2016 Oct 20. PMID 27692986
  4. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
  5. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
    Title: NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
  2. USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
    Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.
  3. suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma
    Title: Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice.
  4. that Nlrp4e, a maternal-zygotic-effect gene, may not be involved in oocyte maturation but may play a critical role in early embryogenesis.
    Title: Developmental expression and possible functional roles of mouse Nlrp4e in preimplantation embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 4E
Names
NACHT, leucine rich repeat and PYD containing 4E
NALP, epsilon
NLR family, pyrin domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004194.2 → NP_001004194.2  NACHT, LRR and PYD domains-containing protein 4E

    See identical proteins and their annotated locations for NP_001004194.2

    Status: VALIDATED

    Source sequence(s)
    AC150900
    Consensus CDS
    CCDS20928.1
    UniProtKB/Swiss-Prot
    Q66X19
    UniProtKB/TrEMBL
    B9EIC2
    Related
    ENSMUSP00000075794.4, ENSMUST00000076470.5
    Conserved Domains (5) summary
    COG4886
    Location:742 → 929
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:681 → 960
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:10 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00034
    Location:666 → 691
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:148 → 316
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    23000617..23061702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242760.1 → XP_030098620.1  NACHT, LRR and PYD domains-containing protein 4E isoform X1

    Conserved Domains (4) summary
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    pfam05729
    Location:161 → 329
    NACHT; NACHT domain
    pfam17776
    Location:464 → 577
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:406 → 462
    NOD2_WH; NOD2 winged helix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66X19.2 GenPept UniProtKB/Swiss-Prot:Q66X19

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