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cd2ap.L CD2-associated protein L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 445851, updated on 4-Nov-2024

Summary

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Official Symbol
cd2ap.L
Official Full Name
CD2-associated protein L homeolog
Primary source
Xenbase:XB-GENE-987814
Locus tag
XELAEV_18028137mg
See related
EnsemblRapid:ENSXLAG00005008553 AllianceGenome:Xenbase:XB-GENE-987814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
cd2ap; cd2ap.S
Summary
Predicted to act upstream of or within actin filament organization and cell migration. Predicted to be located in several cellular components, including cell leading edge; plasma membrane; and vesicle. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cd2ap.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (158104352..158200398, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (147049463..147145551, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene opsin 5 L homeolog Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene tumor necrosis factor receptor superfamily member 21 L homeolog Neighboring gene palmitoyltransferase ZDHHC2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD2-associated protein L homeolog
Names
CD2-associated protein S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092963.1 → NP_001086432.1  CD2-associated protein L homeolog

    See identical proteins and their annotated locations for NP_001086432.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097671
    UniProtKB/TrEMBL
    A0A974HKE6, Q4V7X8
    Related
    ENSXLAP00005024807.1, ENSXLAT00005025516.1
    Conserved Domains (3) summary
    cd12053
    Location:3 → 58
    SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein
    cd12054
    Location:109 → 163
    SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
    cd12056
    Location:277 → 333
    SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    158104352..158200398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041562205.1 → XP_041418139.1  CD2-associated protein L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1KPI2
    Related
    ENSXLAP00005024891.1, ENSXLAT00005025600.1
    Conserved Domains (3) summary
    cd12053
    Location:3 → 55
    SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein
    cd12054
    Location:127 → 181
    SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
    cd12056
    Location:295 → 351
    SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

  2. XM_041562206.1 → XP_041418140.1  CD2-associated protein L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1KLE8, A0A974HKE6
    Conserved Domains (2) summary
    cd12054
    Location:23 → 77
    SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
    cd12056
    Location:191 → 247
    SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

  3. XM_041562207.1 → XP_041418141.1  CD2-associated protein L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1KLE8, A0A974HKE6
    Related
    ENSXLAP00005024746.1, ENSXLAT00005025455.1
    Conserved Domains (2) summary
    cd12054
    Location:23 → 77
    SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
    cd12056
    Location:191 → 247
    SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein

  4. XM_041562208.1 → XP_041418142.1  CD2-associated protein L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1KLD9
    Conserved Domains (3) summary
    cd12053
    Location:3 → 55
    SH3_CD2AP_1; First Src Homology 3 domain (SH3A) of CD2-associated protein
    cd12054
    Location:127 → 181
    SH3_CD2AP_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein
    cd12056
    Location:295 → 351
    SH3_CD2AP_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein
Nucleotide Protein Strain
Heading Accession and Version

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