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smad9 SMAD family member 9 [ Danio rerio (zebrafish) ]

Gene ID: 445564, updated on 2-Nov-2024

Summary

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Official Symbol
smad9provided by ZNC
Official Full Name
SMAD family member 9provided by ZNC
Primary source
ZFIN:ZDB-GENE-031014-1
See related
Ensembl:ENSDARG00000021938 AllianceGenome:ZFIN:ZDB-GENE-031014-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sma8; zgc:103407
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including myeloid cell development; negative regulation of DNA-templated transcription; and regulation of BMP signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See smad9 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (34961604..34981034, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (35017744..35037174, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene cyclin A1 Neighboring gene uncharacterized LOC103911767 Neighboring gene serine rich and transmembrane domain containing 1 Neighboring gene regulatory factor X-associated protein Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene exosome component 8 Neighboring gene SPT20 homolog, SAGA complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Min KD, et al. Sci Rep, 2021 Nov 29. PMID 34845242, Free PMC Article
  2. Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. McDonald GLK, et al. Biomolecules, 2021 Feb 13. PMID 33668680, Free PMC Article
  3. Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. Pant SD, et al. Invest Ophthalmol Vis Sci, 2013 Aug 28. PMID 23847306
  4. Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Kim JD, et al. Mol Cells, 2014 Mar. PMID 24608800, Free PMC Article
  5. The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. Shen Q, et al. J Clin Invest, 2009 Nov. PMID 19855136, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis.
    Title: ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis.
  2. Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations.
    Title: Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations.
  3. this study uncovers that smad1 and smad9 act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.
    Title: Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC103407

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myeloid cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mothers against decapentaplegic homolog 9
Names
MAD homolog 9
madh9
smad8
NP_001315428.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328499.1 → NP_001315428.1  mothers against decapentaplegic homolog 9

    Status: VALIDATED

    Source sequence(s)
    CT573139
    UniProtKB/TrEMBL
    A0A8M1PA28, F1QXZ9
    Related
    ENSDARP00000148074.1, ENSDART00000186108.1
    Conserved Domains (2) summary
    cd10490
    Location:13 → 136
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:266 → 466
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    34961604..34981034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004014.1: Suppressed sequence

    Description
    NM_001004014.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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