HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: HSD3B1
Gene description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
See related: Ensembl:ENSSSCG00000006719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: HSD3B; 3B-HSD
Expression: Biased expression in ovary (RPKM 20.4), liver (RPKM 19.9) and 2 other tissues See more
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (101565229..101574110, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (111555576..111564185, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was concluded that the presence of apelin/APLNR in the CL of pigs and stimulatory effects of apelin on progesterone secretion and 3beta-HSD levels suggest potential auto/paracrine regulation by apelin in the luteal phase of the estrous cycle.
Title: Apelin and apelin receptor at different stages of corpus luteum development and effect of apelin on progesterone secretion and 3β-hydroxysteroid dehydrogenase (3β-HSD) in pigs.
Glucocorticoid receptor binding to 3beta-HSD promoter is involved in the differential hepatic 3beta-HSD expression between boars and barrows.
Title: Glucocorticoid receptor is involved in the differential expression of hepatic 3β-hydroxysteroid dehydrogenase between barrows and boars at finishing stage.
We found that adiponectin and insulin alone regulates the expression of StAR, CYP11A1 and HSD3B1 genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
Title: Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy.
The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD), CYP17, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) in the porcine fetus are reported.
Title: Altered expression of 3β-HSD, CYP17 and 17β-HSD in the foetal porcine gonads in response to anti-androgen flutamide exposure.
Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.
Title: Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs.
New insights to the transcriptional regulation of 3betaHSD1 and 17betaHSD7 and further hints to their involvement in steroid metabolism.
Title: Investigation on the transcription factors of porcine 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase genes.
Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.
Title: In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones.
The expression of 3betaHSD mRNA was detected by the use of RT-PCR technique in all investigated samples isolated at different stages of pregnancy.
Title: The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine.
Significant sequence variations were found in the 5'flanking region of the 3beta-HSD gene, where differences in the number of TTAT repeats and 3 SNP were observed in the different breeds
Title: Breed-associated variations in the sequence of the pig 3beta-hydroxysteroid dehydrogenase gene.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

Names: 3-beta-HSD; 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase

NP_001004049.1

EC 1.1.1.145

EC 5.3.3.1

XP_020944404.1

EC 1.1.1.145

EC 5.3.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004049.2 → NP_001004049.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

See identical proteins and their annotated locations for NP_001004049.1

Status: VALIDATED

Source sequence(s)

AEMK02000024, AF232699, AK235739

UniProtKB/Swiss-Prot

Q9N119

UniProtKB/TrEMBL

A0A8D0NBN7, D0G6Y4

Related

ENSSSCP00000007165.2, ENSSSCT00000007360.6

Conserved Domains (2) summary

pfam01073
Location:7 → 287

3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

cl21454
Location:5 → 357

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010446.5 Reference Sscrofa11.1 Primary Assembly

Range

101565229..101574110 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021088745.1 → XP_020944404.1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase isoform X1

UniProtKB/TrEMBL

A0A8D0NBN7

Conserved Domains (1) summary

cl25409
Location:5 → 383

SDR; Short-chain dehydrogenases/reductases (SDR)