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morc2 MORC family CW-type zinc finger 2 [ Danio rerio (zebrafish) ]

Gene ID: 445488, updated on 28-Oct-2024

Summary

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Official Symbol
morc2provided by ZNC
Official Full Name
MORC family CW-type zinc finger 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-40
See related
Ensembl:ENSDARG00000028539 AllianceGenome:ZFIN:ZDB-GENE-040822-40
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa19f10; zgc:92010; im:6911946; wu:fa19f10
Summary
Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See morc2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (3708087..3745399, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (3582428..3619742, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene inner centromere protein Neighboring gene prion protein, related sequence 3 Neighboring gene zgc:158398 Neighboring gene THO complex 5 Neighboring gene chitinase domain containing 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATPase MORC2
NP_001003994.1
XP_005174293.1
XP_009295992.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003994.1 → NP_001003994.1  ATPase MORC2

    See identical proteins and their annotated locations for NP_001003994.1

    Status: VALIDATED

    Source sequence(s)
    BC080267
    UniProtKB/TrEMBL
    A0A8M2BLV0, Q68EG7
    Related
    ENSDARP00000030104.5, ENSDART00000037973.6
    Conserved Domains (2) summary
    pfam07496
    Location:496 → 542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29 → 161
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    3708087..3745399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297717.4 → XP_009295992.1  ATPase MORC2 isoform X1

    See identical proteins and their annotated locations for XP_009295992.1

    UniProtKB/TrEMBL
    A0A8M2BLV0, Q68EG7
    Conserved Domains (2) summary
    pfam07496
    Location:496 → 542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29 → 161
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  2. XM_005174236.5 → XP_005174293.1  ATPase MORC2 isoform X1

    See identical proteins and their annotated locations for XP_005174293.1

    UniProtKB/TrEMBL
    A0A8M2BLV0, Q68EG7
    Conserved Domains (2) summary
    pfam07496
    Location:496 → 542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29 → 161
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Nucleotide Protein Strain
Heading Accession and Version

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