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Hnf4 Hepatocyte nuclear factor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44544, updated on 2-Nov-2024

Summary

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Official Symbol
Hnf4provided by FlyBase
Official Full Name
Hepatocyte nuclear factor 4provided by FlyBase
Primary source
FLYBASE:FBgn0004914
Locus tag
Dmel_CG9310
See related
AllianceGenome:FB:FBgn0004914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9310; dHNF-4; dHnf4; dHNF4; Dmel\CG9310; DmHNF4; Hnf-4; HNF-4; HNF-4(D); Hnf-4h; hnf4; HNF4; HNF4alpha; NHF4; NR2A4
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in several processes, including cellular response to insulin stimulus; glucose homeostasis; and lipid oxidation. Located in nucleus. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; epithelium; gut section; and oenocyte. Used to study Fanconi syndrome; maturity-onset diabetes of the young; and maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to several human genes including HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Hnf4 in Genome Data Viewer
Location:
29E4-29E4; 2-33 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8687226..8709611, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8687226..8709611, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Prenyl-binding protein Neighboring gene TRAPP subunit 23 Neighboring gene antisense RNA:CR44992 Neighboring gene Catalase B Neighboring gene raw Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
  2. dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster. Almeida-Oliveira F, et al. Insect Biochem Mol Biol, 2021 Jun. PMID 33753225
  3. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation. Zhong W, et al. EMBO J, 1993 Feb. PMID 8440243, Free PMC Article
  4. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4. Sun J, et al. Sci Adv, 2023 Jun 30. PMID 37390217, Free PMC Article
  5. Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Bülow MH, et al. Mol Biol Cell, 2018 Feb 15. PMID 29282281, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut.
    Title: Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut.
  2. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
    Title: Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.
  3. dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster.
    Title: dHNF4 regulates lipid homeostasis and oogenesis in Drosophila melanogaster.
  4. Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A.
    Title: Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A.
  5. establish dHNF4 as a regulator of the adult metabolic state
    Title: Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.
  6. Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS).
    Title: The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults.
  7. Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
    Title: Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.
  8. Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
    Title: Drosophila HNF4 regulates lipid mobilization and beta-oxidation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hepatocyte nuclear factor 4
Names
CG9310-PA
CG9310-PB
CG9310-PD
CG9310-PE
CG9310-PF
Hnf4-PA
Hnf4-PB
Hnf4-PD
Hnf4-PE
Hnf4-PF
hepatocyte nuclear factor 4 homologue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8687226..8709611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164834.2 → NP_723414.2  hepatocyte nuclear factor 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723414.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DYX8, C5WLN3, P49866, Q8IGG2, Q8IPF2, Q9VLI7, Q9VLI8
    Conserved Domains (2) summary
    cd06931
    Location:236 → 466
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:142 → 217
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. NM_057539.5 → NP_476887.2  hepatocyte nuclear factor 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476887.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DYX8, C5WLN3, P49866, Q8IGG2, Q8IPF2, Q9VLI7, Q9VLI8
    Related
    FBpp0079349
    Conserved Domains (2) summary
    cd06931
    Location:236 → 466
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:142 → 217
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  3. NM_001103656.3 → NP_001097126.1  hepatocyte nuclear factor 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Conserved Domains (2) summary
    cd06931
    Location:240 → 470
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:146 → 221
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  4. NM_001298829.1 → NP_001285758.1  hepatocyte nuclear factor 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285758.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9X1
    Conserved Domains (2) summary
    cd06931
    Location:198 → 428
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:104 → 179
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  5. NM_164833.2 → NP_723413.1  hepatocyte nuclear factor 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49866
    Related
    FBpp0079350
    Conserved Domains (2) summary
    cd06931
    Location:264 → 494
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:170 → 245
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49866.3 P49866
X2J9X1 X2J9X1

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