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negr1 neuronal growth regulator 1 [ Danio rerio (zebrafish) ]

Gene ID: 445374, updated on 28-Oct-2024

Summary

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Official Symbol
negr1provided by ZNC
Official Full Name
neuronal growth regulator 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-27
See related
Ensembl:ENSDARG00000021607 AllianceGenome:ZFIN:ZDB-GENE-040822-27
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:100871
Summary
Enables identical protein binding activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in head. Orthologous to human NEGR1 (neuronal growth regulator 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See negr1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (36942966..37247931)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (36964849..37189770)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene TRAF3 interacting protein 2-like Neighboring gene uncharacterized LOC137495990 Neighboring gene zinc finger, RAN-binding domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development. Habicher J, et al. Genes (Basel), 2024 Mar 14. PMID 38540422, Free PMC Article
  2. Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections. Wang X, et al. J Biol Chem, 2016 Feb 19. PMID 26740623, Free PMC Article
  3. Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. Zuccarini G, et al. Int J Mol Sci, 2019 Dec 25. PMID 31881740, Free PMC Article
  4. Neuroprotective effect of plasmalogens on AlCl(3)-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center. Zhang J, et al. Neurosci Lett, 2024 Jan 1. PMID 37979715
  5. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development.
    Title: The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC100871

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuronal growth regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003851.1 → NP_001003851.1  neuronal growth regulator 1 precursor

    See identical proteins and their annotated locations for NP_001003851.1

    Status: PROVISIONAL

    Source sequence(s)
    AF241637
    UniProtKB/TrEMBL
    A0A4W4, A0A564, A0A8N7XJH4, E7FAG9
    Related
    ENSDARP00000038588.6, ENSDART00000028895.7
    Conserved Domains (4) summary
    smart00408
    Location:153 → 208
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:236 → 312
    IG_like; Immunoglobulin like
    pfam07679
    Location:140 → 222
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:42 → 121
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    36942966..37247931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302511.4 → XP_009300786.1  neuronal growth regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B3I9
    Conserved Domains (4) summary
    smart00408
    Location:153 → 208
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:236 → 312
    IG_like; Immunoglobulin like
    pfam07679
    Location:140 → 222
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:42 → 121
    Ig; Immunoglobulin domain

RNA

  1. XR_011015800.1 RNA Sequence

  2. XR_011015802.1 RNA Sequence

  3. XR_011015801.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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