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septin5b septin 5b [ Danio rerio (zebrafish) ]

Gene ID: 445325, updated on 2-Nov-2024

Summary

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Official Symbol
septin5bprovided by ZNC
Official Full Name
septin 5bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-43
See related
Ensembl:ENSDARG00000036031 AllianceGenome:ZFIN:ZDB-GENE-040808-43
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sept5b; zgc:100950
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Is expressed in brain and retina. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See septin5b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (43930802..43964039, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (44089452..44117231, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene toll-like receptor 8b Neighboring gene multiple C2 domains, transmembrane 1b Neighboring gene claudin 5b Neighboring gene acyl-CoA dehydrogenase short chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of sept3, sept5a and sept5b in the Developing and Adult Nervous System of the Zebrafish (Danio rerio). Helmprobst F, et al. Front Neuroanat, 2017. PMID 28261064, Free PMC Article
  2. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. van Leeuwen LM, et al. Biol Open, 2018 Feb 2. PMID 29437557, Free PMC Article
  3. A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Gurung R, et al. Genetics, 2017 Feb. PMID 27879346, Free PMC Article
  4. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
  5. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
septin 5b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003782.2 → NP_001003782.1  septin 5b

    See identical proteins and their annotated locations for NP_001003782.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078256
    UniProtKB/TrEMBL
    Q6AZC9
    Related
    ENSDARP00000007457.9, ENSDART00000009134.9
    Conserved Domains (2) summary
    COG5019
    Location:22 → 366
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:39 → 311
    Septin; Septin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    43930802..43964039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479157.2 → XP_021334832.1  septin 5b isoform X1

    UniProtKB/TrEMBL
    A0A8M9PTI3
    Conserved Domains (1) summary
    pfam00735
    Location:40 → 311
    Septin

  2. XM_068223772.1 → XP_068079873.1  septin 5b isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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