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chrne cholinergic receptor, nicotinic, epsilon [ Danio rerio (zebrafish) ]

Gene ID: 445315, updated on 12-Sep-2024

Summary

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Official Symbol
chrneprovided by ZNC
Official Full Name
cholinergic receptor, nicotinic, epsilonprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040808-32
See related
Ensembl:ENSDARG00000034307 AllianceGenome:ZFIN:ZDB-GENE-040808-32
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7154697; zgc:101010
Summary
Contributes to acetylcholine receptor activity. Acts upstream of or within cellular response to acetylcholine and cholinergic synaptic transmission. Part of acetylcholine-gated channel complex. Is expressed in central nervous system; mesoderm; musculature system; and somite. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See chrne in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38440099..38451115, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37839946..37850962, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene misshapen-like kinase 1 Neighboring gene uncharacterized LOC137490148 Neighboring gene phospholipase D2 Neighboring gene glycolipid transfer protein domain containing 2b Neighboring gene uncharacterized LOC101885954 Neighboring gene ATPase Na+/K+ transporting subunit beta 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. Zempo B, et al. Sci Adv, 2020 Apr. PMID 32284992, Free PMC Article
  2. Early Exposure to THC Alters M-Cell Development in Zebrafish Embryos. Amin MR, et al. Biomedicines, 2020 Jan 4. PMID 31947970, Free PMC Article
  3. A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses. Park JY, et al. J Neurosci, 2014 Jul 30. PMID 25080583, Free PMC Article
  4. An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses. Mongeon R, et al. J Gen Physiol, 2011 Sep. PMID 21844221, Free PMC Article
  5. Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development. Ahmed KT, et al. Dev Neurobiol, 2016 Aug. PMID 26585318

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to acetylcholine IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synaptic transmission, cholinergic IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetylcholine receptor subunit epsilon
Names
AChR epsilon
nicotinic acetylcholine receptor subunit epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327883.1 → NP_001314812.1  acetylcholine receptor subunit epsilon precursor

    Status: PROVISIONAL

    Source sequence(s)
    BX324194, CR854980
    UniProtKB/TrEMBL
    A0A8M1P9H7, A2BG85, F1REB2
    Related
    ENSDARP00000116514.1, ENSDART00000136428.3
    Conserved Domains (3) summary
    TIGR00860
    Location:10 → 495
    LIC; Cation transporter family protein
    pfam02931
    Location:29 → 245
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:252 → 494
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    38440099..38451115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    173955..184555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003772.1: Suppressed sequence

    Description
    NM_001003772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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