eif3ha eukaryotic translation initiation factor 3, subunit H, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif3haprovided by ZNC
Official Full Name: eukaryotic translation initiation factor 3, subunit H, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040808-19
See related: Ensembl:ENSDARG00000102452 AllianceGenome:ZFIN:ZDB-GENE-040808-19
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eif3h; eif3s3; eIF3h-A; fj02c04; wu:fj02c04; zgc:101085
Summary: Predicted to enable metallopeptidase activity. Predicted to contribute to translation initiation factor activity. Acts upstream of or within several processes, including lateral line development; regulation of translation; and vasculature development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including gut; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (48282321..48400650, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (48340303..48458632, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate the role of a noncore eIF3 subunit eif3ha in modulating a specific developmental program by regulating translation of defined transcripts.
Title: Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.
Non-core subunit eif3h of translation intiation factor eIF3 regulates zebrafish embryonic development.
Title: Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit H-A

Names: eIF-3-gamma-A; eukaryotic translation initiation factor 3, subunit 3 (gamma)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003763.2 → NP_001003763.1 eukaryotic translation initiation factor 3 subunit H-A

See identical proteins and their annotated locations for NP_001003763.1

Status: VALIDATED

Source sequence(s)

BI473261, EH509704, FP015828

UniProtKB/Swiss-Prot

Q6AXJ2

Related

ENSDARP00000129950.1, ENSDART00000159372.2

Conserved Domains (1) summary

cd08065
Location:20 → 283

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h