me2 malic enzyme 2, NAD(+)-dependent, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: me2provided by ZNC
Official Full Name: malic enzyme 2, NAD(+)-dependent, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-147
See related: Ensembl:ENSDARG00000100718 AllianceGenome:ZFIN:ZDB-GENE-040801-147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:100941
Summary: Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; hatching gland; musculature system; polster; and visual system. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (6796291..6844099)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (6233724..6281532)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables malic enzyme activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NAD-dependent malic enzyme, mitochondrial

NP_001003627.2

EC 1.1.1.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003627.2 → NP_001003627.2 NAD-dependent malic enzyme, mitochondrial

See identical proteins and their annotated locations for NP_001003627.2

Status: VALIDATED

Source sequence(s)

CT955987, CU856358

UniProtKB/TrEMBL

A0A8M1N1R5, A5PN55

Related

ENSDARP00000132162.1, ENSDART00000165308.2

Conserved Domains (3) summary

cd05312
Location:280 → 559

NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1

PLN03129
Location:18 → 565

PLN03129; NADP-dependent malic enzyme; Provisional

pfam00390
Location:89 → 270

malic; Malic enzyme, N-terminal domain