rab35b RAB35, member RAS oncogene family b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab35bprovided by ZNC
Official Full Name: RAB35, member RAS oncogene family bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-62
See related: Ensembl:ENSDARG00000058425 AllianceGenome:ZFIN:ZDB-GENE-040801-62
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rab35; sb:eu777; dZ146N9.2; zgc:100812; si:busm1-146n9.2
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Predicted to be active in endosome membrane and plasma membrane. Is expressed in Kupffer's vesicle and testis. Orthologous to human RAB35 (RAB35, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (3649070..3674506)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (3590321..3615757)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings demonstrate roles for Rab35 in regulating cilium length.
Title: Rab35 controls cilium length, function and membrane composition.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-related protein Rab-35b

NP_001003548.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003548.2 → NP_001003548.1 ras-related protein Rab-35b

See identical proteins and their annotated locations for NP_001003548.1

Status: PROVISIONAL

Source sequence(s)

BC077124

UniProtKB/TrEMBL

Q6DEJ0

Related

ENSDARP00000039450.6, ENSDART00000033152.7

Conserved Domains (2) summary

smart00175
Location:9 → 170

RAB; Rab subfamily of small GTPases

cl21455
Location:3 → 201

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases