flii.S FLII actin remodeling protein S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: flii.S
Official Full Name: FLII actin remodeling protein S homeolog
Primary source: Xenbase:XB-GENE-865203
Locus tag: XELAEV_18047790mg
See related: EnsemblRapid:ENSXLAG00005011103 AllianceGenome:Xenbase:XB-GENE-865203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: flii; flightless
Summary: Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to act upstream of or within actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (105971567..106010219, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (99327634..99366621, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament severing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibril assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FLII actin remodeling protein S homeolog

Names: flightless 1 homolog; flightless I actin binding protein S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092850.1 → NP_001086319.1 FLII actin remodeling protein S homeolog

See identical proteins and their annotated locations for NP_001086319.1

Status: PROVISIONAL

Source sequence(s)

BC074479

UniProtKB/TrEMBL

A0A974BVY6, Q6DKA2

Related

ENSXLAP00005032637.1, ENSXLAT00005033429.1

Conserved Domains (8) summary

cd11280
Location:620 → 707

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1054 → 1153

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:493 → 605

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:1164 → 1262

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:724 → 838

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

PLN00113
Location:5 → 352

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:342 → 355

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:106 → 128

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

105971567..106010219 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)