U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nt5c2.L 5'-nucleotidase, cytosolic II L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444729, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
nt5c2.L
Official Full Name
5'-nucleotidase, cytosolic II L homeolog
Primary source
Xenbase:XB-GENE-988880
Locus tag
XELAEV_18003908mg
See related
EnsemblRapid:ENSXLAG00005014576 AllianceGenome:Xenbase:XB-GENE-988880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nt5c2
Summary
Predicted to enable several functions, including 5'-nucleotidase activity; ATP binding activity; and nucleoside phosphotransferase activity. Predicted to act upstream of or within GMP metabolic process; IMP metabolic process; and dGMP metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nt5c2.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
24
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (24156234..24252752)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694852.1 (633605..698995, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 6 Neighboring gene ubiquitin carboxyl-terminal hydrolase 42-like Neighboring gene ubiquitin carboxyl-terminal hydrolase 42-like Neighboring gene ubiquitin carboxyl-terminal hydrolase 36-like Neighboring gene uncharacterized LOC121395346 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC84715

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GMP 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables GMP 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables IMP 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables IMP 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside phosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GMP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within IMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within IMP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within adenosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dGMP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytosolic purine 5'-nucleotidase
Names
cytosolic 5'-nucleotidase II
cytosolic nucleoside phosphotransferase 5'N
NP_001086300.1
XP_018097164.1
XP_041424422.1
XP_041424423.1
XP_041424424.1
XP_041424425.1
XP_041424426.1
XP_041424427.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092831.1 → NP_001086300.1  cytosolic purine 5'-nucleotidase

    See identical proteins and their annotated locations for NP_001086300.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074446
    UniProtKB/Swiss-Prot
    Q6DKB0
    UniProtKB/TrEMBL
    A0A974H9P4
    Related
    ENSXLAP00005042649.1, ENSXLAT00005043716.1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    24156234..24252752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568489.1 → XP_041424423.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/TrEMBL
    A0A310UF24, A0A974BS09, A0A974H9P4, A0AA97PYK8
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 503
    5_nucleotid; 5' nucleotidase family

  2. XM_041568491.1 → XP_041424425.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/TrEMBL
    A0A310UF24, A0A974BS09, A0A974H9P4, A0AA97PYK8
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 503
    5_nucleotid; 5' nucleotidase family

  3. XM_018241675.2 → XP_018097164.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/TrEMBL
    A0A310UF24, A0A974BS09, A0A974H9P4, A0AA97PYK8
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 503
    5_nucleotid; 5' nucleotidase family

  4. XM_041568490.1 → XP_041424424.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/TrEMBL
    A0A310UF24, A0A974BS09, A0A974H9P4, A0AA97PYK8
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 503
    5_nucleotid; 5' nucleotidase family

  5. XM_041568488.1 → XP_041424422.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A8J1L4F0, A0A974H9P4
    Related
    ENSXLAP00005042659.1, ENSXLAT00005043726.1
    Conserved Domains (1) summary
    cd07522
    Location:49 → 491
    HAD_cN-II; cytosolic 5'-nucleotidase II (cN-II) similar to human NT5DC1 (5'-nucleotidase domain-containing protein 1) and NT5DC2

  6. XM_041568492.1 → XP_041424426.1  cytosolic purine 5'-nucleotidase isoform X3

    UniProtKB/TrEMBL
    A0A8J1L4F4, A0A974H9P4
    Related
    ENSXLAP00005042661.1, ENSXLAT00005043728.1
    Conserved Domains (1) summary
    cd07522
    Location:49 → 476
    HAD_cN-II; cytosolic 5'-nucleotidase II (cN-II) similar to human NT5DC1 (5'-nucleotidase domain-containing protein 1) and NT5DC2

  7. XM_041568493.1 → XP_041424427.1  cytosolic purine 5'-nucleotidase isoform X4

    UniProtKB/TrEMBL
    A0A8J1L4F5
    Related
    ENSXLAP00005042646.1, ENSXLAT00005043713.1
    Conserved Domains (1) summary
    cd07522
    Location:23 → 465
    HAD_cN-II; cytosolic 5'-nucleotidase II (cN-II) similar to human NT5DC1 (5'-nucleotidase domain-containing protein 1) and NT5DC2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DKB0.1 GenPept UniProtKB/Swiss-Prot:Q6DKB0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.