aco2.S aconitase 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aco2.S
Official Full Name: aconitase 2 S homeolog
Primary source: Xenbase:XB-GENE-1000791
Locus tag: XELAEV_18025669mg
See related: EnsemblRapid:ENSXLAG00005005758 AllianceGenome:Xenbase:XB-GENE-1000791
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: aco2
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and metal ion binding activity. Predicted to act upstream of or within tricarboxylic acid cycle. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (100637050..100659084)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (94314975..94337042)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aconitase 2 S homeolog

Names: aconitase 2, mitochondrial

NP_001086263.1

EC 4.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092794.1 → NP_001086263.1 aconitase 2 S homeolog

See identical proteins and their annotated locations for NP_001086263.1

Status: PROVISIONAL

Source sequence(s)

BC074399

UniProtKB/TrEMBL

A0A974D2T8, Q6DKB9, Q9PUG0

Related

ENSXLAP00005017260.1, ENSXLAT00005017556.1

Conserved Domains (3) summary

cd01584
Location:97 → 507

AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle

cd01578
Location:589 → 737

AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...

TIGR01340
Location:47 → 777

aconitase_mito; aconitate hydratase, mitochondrial