alad.L aminolevulinate dehydratase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: alad.L
Official Full Name: aminolevulinate dehydratase L homeolog
Primary source: Xenbase:XB-GENE-962180
Locus tag: XELAEV_18038183mg
See related: EnsemblRapid:ENSXLAG00005018984 AllianceGenome:Xenbase:XB-GENE-962180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: alad
Summary: Predicted to enable porphobilinogen synthase activity and zinc ion binding activity. Predicted to act upstream of or within protoporphyrinogen IX biosynthetic process. Predicted to be located in cytosol. Is expressed in ectoderm. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (1642355..1647871)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (1469040..1474663)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables porphobilinogen synthase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminolevulinate dehydratase L homeolog

Names: aminolevulinate, delta-, dehydratase

NP_001085993.1

EC 4.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092524.1 → NP_001085993.1 aminolevulinate dehydratase L homeolog

See identical proteins and their annotated locations for NP_001085993.1

Status: PROVISIONAL

Source sequence(s)

BC073664

UniProtKB/TrEMBL

A0A974H778, Q6GN55

Related

ENSXLAP00005056011.1, ENSXLAT00005057240.1

Conserved Domains (1) summary

cd04824
Location:8 → 327

eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...