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serpinf1.L serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444412, updated on 4-Nov-2024

Summary

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Official Symbol
serpinf1.L
Official Full Name
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog
Primary source
Xenbase:XB-GENE-945031
Locus tag
XELAEV_18011731mg
See related
EnsemblRapid:ENSXLAG00005024593 AllianceGenome:Xenbase:XB-GENE-945031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
PEDF; serpinf1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of angiogenesis; negative regulation of endopeptidase activity; and positive regulation of neurogenesis. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See serpinf1.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (36105793..36145985, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (35036758..35076952, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 L homeolog Neighboring gene replication protein A1 L homeolog Neighboring gene SET and MYND domain containing 4 L homeolog Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 L homeolog Neighboring gene WD repeat domain 81 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82984

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog
Names
Pigment epithelium-derived factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092514.1 → NP_001085983.1  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog precursor

    See identical proteins and their annotated locations for NP_001085983.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073647
    UniProtKB/TrEMBL
    A0A974HXQ8, Q6GN71
    Related
    ENSXLAP00005072848.1, ENSXLAT00005074407.1
    Conserved Domains (1) summary
    cd02052
    Location:34 → 404
    PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    36105793..36145985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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