nfatc1.L nuclear factor of activated T cells 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nfatc1.L
Official Full Name: nuclear factor of activated T cells 1 L homeolog
Primary source: Xenbase:XB-GENE-876764
Locus tag: XELAEV_18031751mg
See related: EnsemblRapid:ENSXLAG00005010005 AllianceGenome:Xenbase:XB-GENE-876764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nfat2; nfatc; nf-atc; nfatc1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within calcineurin-NFAT signaling cascade and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (103123842..103252794, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (96242158..96371505, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor of activated T cells 1 L homeolog

Names: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092450.1 → NP_001085919.1 nuclear factor of activated T cells 1 L homeolog

See identical proteins and their annotated locations for NP_001085919.1

Status: PROVISIONAL

Source sequence(s)

BC073536

UniProtKB/TrEMBL

Q6GNH6

Related

ENSXLAP00005029495.1, ENSXLAT00005030241.1

Conserved Domains (2) summary

cd07881
Location:410 → 584

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:589 → 689

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

103123842..103252794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)