dhx58.L DEXH-box helicase 58 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dhx58.L
Official Full Name: DEXH-box helicase 58 L homeolog
Primary source: Xenbase:XB-GENE-992481
Locus tag: XELAEV_18043084mg
See related: EnsemblRapid:ENSXLAG00005035436 AllianceGenome:Xenbase:XB-GENE-992481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: dhx58
Summary: Predicted to enable several functions, including ATP binding activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to act upstream of or within antiviral innate immune response and negative regulation of RIG-I signaling pathway. Predicted to be located in cytoplasm. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (721270..731336)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (680958..691024)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antiviral innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DEXH-box helicase 58 L homeolog

Names: DEXH (Asp-Glu-X-His) box polypeptide 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092446.2 → NP_001085915.1 DEXH-box helicase 58 L homeolog

See identical proteins and their annotated locations for NP_001085915.1

Status: PROVISIONAL

Source sequence(s)

BC073528

UniProtKB/TrEMBL

A0A974H2H1, Q6GNI3

Related

ENSXLAP00005106083.1, ENSXLAT00005108158.1

Conserved Domains (5) summary

COG1111
Location:2 → 535

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cd15806
Location:555 → 666

LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor

cd12090
Location:228 → 347

MDA5_ID; Insert domain of MDA5

pfam00271
Location:353 → 475

Helicase_C; Helicase conserved C-terminal domain

pfam04851
Location:1 → 171

ResIII; Type III restriction enzyme, res subunit