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chn2.L chimerin 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444340, updated on 17-Aug-2024

Summary

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Official Symbol
chn2.L
Official Full Name
chimerin 2 L homeolog
Primary source
Xenbase:XB-GENE-950877
Locus tag
XELAEV_18031012mg
See related
EnsemblRapid:ENSXLAG00005013190
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
chn2; chn1.L
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Genomic context

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Location:
chromosome: 6L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (44577810..44748055)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (40915147..40953026)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene TLR4 interactor with leucine-rich repeats L homeolog Neighboring gene carboxypeptidase, vitellogenic-like L homeolog Neighboring gene proline rich 15 L homeolog Neighboring gene WAS/WASL-interacting protein family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82782

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chimerin 2 L homeolog
Names
chimerin (chimaerin) 2
chimerin 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092444.1 → NP_001085913.1  chimerin 2 L homeolog

    See identical proteins and their annotated locations for NP_001085913.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073525
    UniProtKB/TrEMBL
    A0A974CJB1, A0A974HFM7, Q6GNI5
    Related
    ENSXLAP00005038897.1, ENSXLAT00005039819.1
    Conserved Domains (2) summary
    cd04372
    Location:139 → 332
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:79 → 131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    44577810..44748055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041565431.1 → XP_041421365.1  chimerin 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8FW74, A0A974CNG8
    Related
    ENSXLAP00005038911.1, ENSXLAT00005039832.1
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:274 → 467
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:209 → 269
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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