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mef2c.L MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444310, updated on 4-Nov-2024

Summary

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Official Symbol
mef2c.L
Official Full Name
MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog
Primary source
Xenbase:XB-GENE-865661
Locus tag
XELAEV_18008088mg
See related
EnsemblRapid:ENSXLAG00005005872 AllianceGenome:Xenbase:XB-GENE-865661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mef2c; XMEF2C
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in cardiovascular system; mesenchyme; musculoskeletal system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mef2c.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (194988749..195176108)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (181846770..182034585)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene centrin 3 L homeolog Neighboring gene uncharacterized LOC121395338 Neighboring gene uncharacterized LOC121395339 Neighboring gene transmembrane protein 161B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus laevis. Guo Y, et al. PLoS One, 2014. PMID 24489892, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mef2c and Mef2d are required for proper cardiac gene expression.
    Title: Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus laevis.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC80986

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092414.1 → NP_001085883.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog

    See identical proteins and their annotated locations for NP_001085883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073471
    UniProtKB/TrEMBL
    Q6GNN3
    Conserved Domains (3) summary
    COG5068
    Location:1 → 274
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    194988749..195176108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041580412.1 → XP_041436346.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X15

    UniProtKB/TrEMBL
    A0A8J1M4X7
    Conserved Domains (2) summary
    COG5068
    Location:1 → 245
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  2. XM_041580400.1 → XP_041436334.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X12

    UniProtKB/TrEMBL
    A0A8J1M3R2
    Conserved Domains (2) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  3. XM_041580369.1 → XP_041436303.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J1M3N2
    Conserved Domains (2) summary
    COG5068
    Location:1 → 296
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  4. XM_041580419.1 → XP_041436353.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X16

    UniProtKB/TrEMBL
    A0A8J1M3S9
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  5. XM_041580378.1 → XP_041436312.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J1M3P2
    Conserved Domains (1) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  6. XM_041580425.1 → XP_041436359.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X18

    UniProtKB/TrEMBL
    Q6GNN3
    Conserved Domains (3) summary
    COG5068
    Location:1 → 274
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  7. XM_041580341.1 → XP_041436275.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1M3K9
    Conserved Domains (2) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  8. XM_041580406.1 → XP_041436340.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X13

    UniProtKB/TrEMBL
    A0A8J1M5L4
    Conserved Domains (2) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  9. XM_041580352.1 → XP_041436286.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1M4S0
    Conserved Domains (2) summary
    COG5068
    Location:1 → 260
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  10. XM_041580367.1 → XP_041436301.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1M4T6
    Related
    ENSXLAP00005017539.1, ENSXLAT00005017835.1
    Conserved Domains (2) summary
    COG5068
    Location:1 → 292
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  11. XM_041580377.1 → XP_041436311.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J1M4U6
    Conserved Domains (2) summary
    COG5068
    Location:1 → 243
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  12. XM_041580421.1 → XP_041436355.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X17

    UniProtKB/TrEMBL
    A0A8J1M5M9
    Conserved Domains (2) summary
    COG5068
    Location:1 → 275
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  13. XM_041580383.1 → XP_041436317.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J1M3P7
    Conserved Domains (2) summary
    COG5068
    Location:1 → 281
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  14. XM_041580372.1 → XP_041436306.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J1M5I4
    Conserved Domains (1) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  15. XM_041580408.1 → XP_041436342.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X14

    UniProtKB/TrEMBL
    A0A8J1M3S1
    Conserved Domains (3) summary
    COG5068
    Location:1 → 261
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  16. XM_041580431.1 → XP_041436365.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X19

    UniProtKB/TrEMBL
    A0A8J1M5N9
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:107 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  17. XM_041580361.1 → XP_041436295.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1M5G1
    Conserved Domains (3) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:117 → 170
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  18. XM_041580393.1 → XP_041436327.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X11

    UniProtKB/TrEMBL
    A0A8J1M3Q7
    Related
    ENSXLAP00005017548.1, ENSXLAT00005017844.1
    Conserved Domains (2) summary
    COG5068
    Location:1 → 275
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  19. XM_018245371.2 → XP_018100860.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X10

    UniProtKB/TrEMBL
    A0A1L8I1W6, A0A974E1Y8

  20. XM_041580348.1 → XP_041436282.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1M3K9
    Conserved Domains (2) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  21. XM_041580376.1 → XP_041436310.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J1M5I4
    Related
    ENSXLAP00005017568.1, ENSXLAT00005017864.1
    Conserved Domains (1) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  22. XM_041580350.1 → XP_041436284.1  MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1M3K9
    Conserved Domains (2) summary
    COG5068
    Location:1 → 263
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
Nucleotide Protein Strain
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