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get3.S guided entry of tail-anchored proteins factor 3, ATPase S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444297, updated on 4-Nov-2024

Summary

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Official Symbol
get3.S
Official Full Name
guided entry of tail-anchored proteins factor 3, ATPase S homeolog
Primary source
Xenbase:XB-GENE-1013231
Locus tag
XELAEV_18000816mg
See related
EnsemblRapid:ENSXLAG00005011405 AllianceGenome:Xenbase:XB-GENE-1013231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
get3; arsa1; asna1; arsa-i; asnal1; asna1.S
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane and protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum. Predicted to be part of GET complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See get3.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (125753750..125763950)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694811.1 (2253585..2264023)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene transportin 2 S homeolog Neighboring gene small nucleolar RNA SNORD41 Neighboring gene telomerase RNA component interacting RNase S homeolog Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit S homeolog Neighboring gene paralemmin 3 S homeolog Neighboring gene MISP family member 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
  2. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC80960

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GET complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATPase GET3
Names
arsA arsenite transporter, ATP-binding, homolog 1 S homeolog
arsenical resistance ATPase
arsenite-translocating ATPase
arsenite-transporting ATPase
NP_001085870.1
XP_018095004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092401.1 → NP_001085870.1  ATPase GET3

    See identical proteins and their annotated locations for NP_001085870.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073453
    UniProtKB/Swiss-Prot
    Q6GNQ1
    Related
    ENSXLAP00005033352.1, ENSXLAT00005034191.1
    Conserved Domains (2) summary
    COG0003
    Location:30 → 332
    ArsA; Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism]
    pfam02374
    Location:31 → 334
    ArsA_ATPase; Anion-transporting ATPase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    125753750..125763950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018239515.2 → XP_018095004.1  ATPase GET3 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TUF9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GNQ1.1 GenPept UniProtKB/Swiss-Prot:Q6GNQ1

Gene LinkOut

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