mlh3.L mutL homolog 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mlh3.L
Official Full Name: mutL homolog 3 L homeolog
Primary source: Xenbase:XB-GENE-991855
Locus tag: XELAEV_18039453mg
See related: EnsemblRapid:ENSXLAG00005017229 AllianceGenome:Xenbase:XB-GENE-991855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mlh3
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent DNA damage sensor activity. Predicted to act upstream of or within mismatch repair. Predicted to be located in nucleus. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (73409590..73437715, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (59923214..59950513, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mismatch repair complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mutL homolog 3 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092327.1 → NP_001085796.2 mutL homolog 3 L homeolog

Status: PROVISIONAL

Source sequence(s)

BC073356

UniProtKB/TrEMBL

A0A8J0PX07, Q6GNZ4

Related

ENSXLAP00005050825.1, ENSXLAT00005051987.1

Conserved Domains (4) summary

smart00853
Location:1034 → 1214

MutL_C; MutL C terminal dimerisation domain

cd03486
Location:206 → 348

MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...

TIGR00585
Location:1 → 325

mutl; DNA mismatch repair protein MutL

pfam02518
Location:24 → 77

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

73409590..73437715 complement

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GenBank, FASTA, Sequence Viewer (Graphics)