kmt5b.S lysine methyltransferase 5B S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kmt5b.S
Official Full Name: lysine methyltransferase 5B S homeolog
Primary source: Xenbase:XB-GENE-866439
Locus tag: XELAEV_18024195mg
See related: EnsemblRapid:ENSXLAG00005008667 AllianceGenome:Xenbase:XB-GENE-866439
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cgi85; kmt5b; cgi-85; kmt5b-a; suv420h1; suv420h1-a
Summary: Predicted to enable S-adenosyl-L-methionine binding activity; chromatin binding activity; and histone H4K20 methyltransferase activity. Predicted to act upstream of or within DNA repair; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to human KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (1400011..1419161, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (1385629..1404776, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K20 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of isotype switching	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase KMT5B-A

Names: [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1-A; lysine (K)-specific methyltransferase 5B S homeolog; lysine-specific methyltransferase 5B-A; su(var)4-20 homolog 1-A; suppressor of variegation 4-20 homolog 1; suppressor of variegation 4-20 homolog 1-A; suv4-20 h1; suv4-20h1-A

NP_001085777.1

EC 2.1.1.361

EC 2.1.1.362

XP_018115082.1

EC 2.1.1.361

EC 2.1.1.362

XP_018115083.1

EC 2.1.1.361

EC 2.1.1.362

XP_018115084.1

EC 2.1.1.361

EC 2.1.1.362

XP_018115085.1

EC 2.1.1.361

EC 2.1.1.362

XP_018115086.1

EC 2.1.1.361

EC 2.1.1.362

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.