gpi.S glucose-6-phosphate isomerase S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gpi.S
Official Full Name: glucose-6-phosphate isomerase S homeolog
Primary source: Xenbase:XB-GENE-944063
Locus tag: XELAEV_18001932mg
See related: EnsemblRapid:ENSXLAG00005010126 AllianceGenome:Xenbase:XB-GENE-944063
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gpi
Summary: Predicted to enable several functions, including cytokine activity; glucose-6-phosphate isomerase activity; and monosaccharide binding activity. Predicted to act upstream of or within gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol and extracellular space. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (49343004..49368000, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694816.1 (2347335..2372400, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose-6-phosphate isomerase S homeolog

Names: glucose phosphate isomerase

NP_001085765.1

EC 5.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092296.1 → NP_001085765.1 glucose-6-phosphate isomerase S homeolog

See identical proteins and their annotated locations for NP_001085765.1

Status: PROVISIONAL

Source sequence(s)

BC073315

UniProtKB/TrEMBL

Q6GP33

Related

ENSXLAP00005029845.1, ENSXLAT00005030595.1

Conserved Domains (3) summary

PRK00179
Location:1 → 552

pgi; glucose-6-phosphate isomerase; Reviewed

cd05015
Location:122 → 285

SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

cd05016
Location:333 → 524

SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

49343004..49368000 complement

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