becn1.L beclin 1, autophagy related L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: becn1.L
Official Full Name: beclin 1, autophagy related L homeolog
Primary source: Xenbase:XB-GENE-999325
Locus tag: XELAEV_18043781mg
See related: EnsemblRapid:ENSXLAG00005029217 AllianceGenome:Xenbase:XB-GENE-999325
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: becn1; beclin1
Summary: Predicted to act upstream of or within several processes, including early endosome to late endosome transport; positive regulation of autophagy; and regulation of cytokinesis. Predicted to be located in several cellular components, including autophagosome; endosome membrane; and phagophore assembly site. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (34442344..34453948, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (24462534..24472216)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to nitrogen starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within late endosome to vacuole transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beclin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092282.1 → NP_001085751.1 beclin-1

See identical proteins and their annotated locations for NP_001085751.1

Status: PROVISIONAL

Source sequence(s)

BC073292

UniProtKB/Swiss-Prot

Q6GP52

UniProtKB/TrEMBL

A0A8J1LSS5

Related

ENSXLAP00005087434.1, ENSXLAT00005089096.1

Conserved Domains (3) summary

pfam15285
Location:102 → 124

BH3; Beclin-1 BH3 domain, Bcl-2-interacting

pfam04111
Location:262 → 440

APG6; Autophagy protein Apg6

pfam17675
Location:130 → 256

APG6_N; Apg6 coiled-coil region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

34442344..34453948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)