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clcn7.L chloride channel, voltage-sensitive 7 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444161, updated on 4-Nov-2024

Summary

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Official Symbol
clcn7.L
Official Full Name
chloride channel, voltage-sensitive 7 L homeolog
Primary source
Xenbase:XB-GENE-995173
Locus tag
XELAEV_18045598mg
See related
EnsemblRapid:ENSXLAG00005035711 AllianceGenome:Xenbase:XB-GENE-995173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
clcn7
Summary
Predicted to enable voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in lysosomal membrane. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clcn7.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
25
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (123415888..123456301, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (112789054..112829606, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized XB940087 L homeolog Neighboring gene protein FAM135A-like Neighboring gene uncharacterized LOC108701696 Neighboring gene uncharacterized LOC108702065 Neighboring gene pentraxin 4 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80627

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables chloride transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chloride channel, voltage-sensitive 7 L homeolog
Names
chloride channel 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092265.1 → NP_001085734.1  chloride channel, voltage-sensitive 7 L homeolog

    See identical proteins and their annotated locations for NP_001085734.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073264
    UniProtKB/TrEMBL
    A0A974C0S1, Q6GP77
    Related
    ENSXLAP00005106797.1, ENSXLAT00005108909.1
    Conserved Domains (4) summary
    COG0517
    Location:733 → 789
    CBS; CBS domain [Signal transduction mechanisms]
    cd03685
    Location:88 → 613
    ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
    cd04591
    Location:631 → 784
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:179 → 588
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    123415888..123456301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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