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atxn3.L ataxin 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444085, updated on 4-Nov-2024

Summary

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Official Symbol
atxn3.L
Official Full Name
ataxin 3 L homeolog
Primary source
Xenbase:XB-GENE-971507
Locus tag
XELAEV_18039546mg
See related
EnsemblRapid:ENSXLAG00005017795 AllianceGenome:Xenbase:XB-GENE-971507
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
atxn3
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination and proteolysis. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Orthologous to human ATXN3 (ataxin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atxn3.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (78250378..78265025, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (64821332..64838257, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene fibulin 5 L homeolog Neighboring gene thyroid hormone receptor interactor 11 L homeolog Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 L homeolog Neighboring gene cleavage and polyadenylation specific factor 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC83584

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ataxin 3 L homeolog; ataxin-3
XP_018084375.1
XP_018084376.1
XP_041428950.1
XP_041428951.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    78250378..78265025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041573016.1 → XP_041428950.1  ataxin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8J1LJS6, A0A974C804
    Related
    ENSXLAP00005052583.1, ENSXLAT00005053755.1

  2. XM_018228886.2 → XP_018084375.1  ataxin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TGK1, A0A974C804
    Related
    ENSXLAP00005052546.1, ENSXLAT00005053718.1

  3. XM_041573017.1 → XP_041428951.1  ataxin-3 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LHX0, Q6GPL1
    Conserved Domains (2) summary
    pfam02099
    Location:2 → 126
    Josephin
    cl27223
    Location:179 → 293
    CBF; CBF/Mak21 family

  4. XM_018228887.2 → XP_018084376.1  ataxin-3 isoform X3

    UniProtKB/TrEMBL
    A0A8J1LHX0, Q6GPL1
    Related
    ENSXLAP00005052563.1, ENSXLAT00005053735.1
    Conserved Domains (2) summary
    pfam02099
    Location:2 → 126
    Josephin
    cl27223
    Location:179 → 293
    CBF; CBF/Mak21 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001092190.1: Suppressed sequence

    Description
    NM_001092190.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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