aurkb.S aurora kinase B S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: aurkb.S
Official Full Name: aurora kinase B S homeolog
Primary source: Xenbase:XB-GENE-6256242
Locus tag: XELAEV_18000887mg
See related: EnsemblRapid:ENSXLAG00005010259 AllianceGenome:Xenbase:XB-GENE-6256242
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: AurB; aik2; aim1; ark2; ipl1; stk5; airk2; stk12; AIRK2-B; aurkb-a; aurkb-b; XAIRK2-B
Summary: Predicted to enable histone H3S10 kinase activity. Predicted to act upstream of or within several processes, including cytokinetic process; mitotic spindle midzone assembly; and regulation of cell cycle process. Predicted to be located in chromosome; midbody; and nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in kinetochore. Orthologous to human AURKB (aurora kinase B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (127578336..127605546)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694811.1 (4072804..4099519)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest a model in which microtubules act as scaffolds for the enzymatic activity of Aurora-B.
Title: Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality.
Data report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP) activator and with the small molecule inhibitor Hesperadin.
Title: Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a.
Title: ICIS and Aurora B coregulate the microtubule depolymerase Kif2a.
the Aurora B chromosome passenger protein complex, including INCENP and survivin, is regulated during oocyte maturation in Xenopus laevis
Title: Regulation of the Aurora B chromosome passenger protein complex during oocyte maturation in Xenopus laevis.
This study reveals a new role for Aurora B, which is to prevent excess MCAK binding to chromatin to facilitate chromatin-nucleated spindle assembly.
Title: Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function.
MCAK regulation of cytoplasmic and spindle-associated microtubules can be differentiated by Aurora B-dependent phosphorylation
Title: Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.
results suggest an essential combined function of AurA and AurB in chromosome segregation and anaphase MT dynamics
Title: Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.
Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism.
Title: Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within midbody abscission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
part_of chromosome passenger complex	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IEA Inferred from Electronic Annotation more info
located_in spindle pole centrosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aurora kinase B-B

Names: aurora B; aurora-B-B; aurora/IPL1-related kinase 2-B; serine/threonine-protein kinase 12-B; serine/threonine-protein kinase aurora-B-B; xAurora-B-B

NP_001085657.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092188.1 → NP_001085657.1 aurora kinase B-B

See identical proteins and their annotated locations for NP_001085657.1

Status: PROVISIONAL

Source sequence(s)

BC073103

UniProtKB/Swiss-Prot

Q6GPL3

Related

ENSXLAP00005030299.1, ENSXLAT00005031056.1

Conserved Domains (2) summary

smart00220
Location:100 → 350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14117
Location:93 → 362

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins