hadha.S hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hadha.S
Official Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha S homeolog
Primary source: Xenbase:XB-GENE-959224
Locus tag: XELAEV_18030252mg
See related: EnsemblRapid:ENSXLAG00005005433 AllianceGenome:Xenbase:XB-GENE-959224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hadha
Summary: Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding activity; and enoyl-CoA hydratase activity. Predicted to act upstream of or within fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (140572740..140596048, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (133808172..133831599, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha S homeolog

Names: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit S homeolog; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092149.1 → NP_001085618.1 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha S homeolog

See identical proteins and their annotated locations for NP_001085618.1

Status: PROVISIONAL

Source sequence(s)

BC073030

UniProtKB/TrEMBL

A0A974CTN7, Q6GPS9

Related

ENSXLAP00005016190.1, ENSXLAT00005016478.1

Conserved Domains (4) summary

cd06558
Location:38 → 248

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

TIGR02441
Location:24 → 759

fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial

pfam00725
Location:541 → 636

3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

pfam02737
Location:360 → 538

3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

140572740..140596048 complement

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GenBank, FASTA, Sequence Viewer (Graphics)