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dtl.L denticleless E3 ubiquitin protein ligase homolog L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 444035, updated on 18-Sep-2024

Summary

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Official Symbol
dtl.L
Official Full Name
denticleless E3 ubiquitin protein ligase homolog L homeolog
Primary source
Xenbase:XB-GENE-985629
Locus tag
XELAEV_18026201mg
See related
EnsemblRapid:ENSXLAG00005026946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dtl; cdt2; ramp; dcaf2; dtl-b; l2dtl; cdt2-b
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Genomic context

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See dtl.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (11521519..11566476)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (10801454..10846796)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 1 L homeolog Neighboring gene lysophosphatidylglycerol acyltransferase 1 L homeolog Neighboring gene uncharacterized LOC121393601 Neighboring gene protein phosphatase 2 regulatory subunit B', beta L homeolog Neighboring gene proton activated chloride channel 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thymine DNA glycosylase is a CRL4Cdt2 substrate. Slenn TJ, et al. J Biol Chem, 2014 Aug 15. PMID 24947512, Free PMC Article
  2. Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation. Zhu XN, et al. Cell Div, 2013 Apr 22. PMID 23607668, Free PMC Article
  3. Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Havens CG, et al. Mol Cell, 2009 Jul 10. PMID 19595719, Free PMC Article
  4. The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA. Kim DH, et al. Mol Cell Biol, 2010 Sep. PMID 20606006, Free PMC Article
  5. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC82606

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Cul4B-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
denticleless protein homolog B
Names
denticleless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092140.1 → NP_001085609.1  denticleless protein homolog B

    See identical proteins and their annotated locations for NP_001085609.1

    Status: PROVISIONAL

    Source sequence(s)
    BC073015
    UniProtKB/Swiss-Prot
    Q6GPU3
    UniProtKB/TrEMBL
    A0A974CTH0
    Related
    ENSXLAP00005080247.1, ENSXLAT00005081841.1
    Conserved Domains (3) summary
    COG2319
    Location:55 → 410
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:55 → 390
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:53 → 95
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    11521519..11566476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GPU3.1 GenPept UniProtKB/Swiss-Prot:Q6GPU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials