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c8a.L complement C8 alpha chain L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443975, updated on 4-Nov-2024

Summary

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Official Symbol
c8a.L
Official Full Name
complement C8 alpha chain L homeolog
Primary source
Xenbase:XB-GENE-980236
Locus tag
XELAEV_18023030mg
See related
EnsemblRapid:ENSXLAG00005033713 AllianceGenome:Xenbase:XB-GENE-980236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
c8a
Summary
Predicted to act upstream of or within complement activation, alternative pathway; complement activation, classical pathway; and killing of cells of another organism. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of membrane attack complex. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See c8a.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (82221607..82235412, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (76933592..76947397, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene Dab, reelin signal transducer, homolog 1 L homeolog Neighboring gene uncharacterized LOC108714248 Neighboring gene FYN-binding protein 1 Neighboring gene complement C8 beta chain L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80388

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within complement activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C8 alpha chain L homeolog
Names
complement component 8, alpha polypeptide L homeolog
complement component C8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092080.1 → NP_001085549.1  complement C8 alpha chain L homeolog precursor

    See identical proteins and their annotated locations for NP_001085549.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072917
    UniProtKB/TrEMBL
    A0A974HPB2, Q6GQ31
    Related
    ENSXLAP00005100713.1, ENSXLAT00005102672.1
    Conserved Domains (3) summary
    smart00209
    Location:547 → 589
    TSP1; Thrombospondin type 1 repeats
    pfam00057
    Location:102 → 133
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam01823
    Location:270 → 495
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    82221607..82235412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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