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edem3.L ER degradation enhancer, mannosidase alpha-like 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443907, updated on 4-Nov-2024

Summary

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Official Symbol
edem3.L
Official Full Name
ER degradation enhancer, mannosidase alpha-like 3 L homeolog
Primary source
Xenbase:XB-GENE-5811512
Locus tag
XELAEV_18023493mg
See related
EnsemblRapid:ENSXLAG00005013180 AllianceGenome:Xenbase:XB-GENE-5811512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
edem3
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to act upstream of or within several processes, including protein alpha-1,2-demannosylation; protein glycosylation; and response to unfolded protein. Predicted to be located in endoplasmic reticulum lumen and membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See edem3.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (110792569..110828606)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (105540566..105576377)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 2 Neighboring gene ring finger protein 2 L homeolog Neighboring gene meiosis inhibitor protein 1-like Neighboring gene meiosis inhibitor protein 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80179

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endoplasmic reticulum mannose trimming IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mannose trimming involved in glycoprotein ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 3
Names
ER degradation-enhancing alpha-mannosidase-like 3
alpha-1,2-mannosidase EDEM3
NP_001085481.2
XP_041445198.1
XP_041445199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092012.1 → NP_001085481.2  ER degradation-enhancing alpha-mannosidase-like protein 3 precursor

    See identical proteins and their annotated locations for NP_001085481.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072826
    UniProtKB/Swiss-Prot
    Q6GQB9
    UniProtKB/TrEMBL
    A0A974D579
    Related
    ENSXLAP00005038909.1, ENSXLAT00005039830.1
    Conserved Domains (2) summary
    cd02126
    Location:650 → 776
    PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
    pfam01532
    Location:45 → 484
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    110792569..110828606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589264.1 → XP_041445198.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MV30, A0A974D579
    Related
    ENSXLAP00005038881.1, ENSXLAT00005039802.1
    Conserved Domains (2) summary
    cd02126
    Location:650 → 776
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    cl04955
    Location:39 → 484
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

  2. XM_041589265.1 → XP_041445199.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8J1MTP0, A0A974D579
    Related
    ENSXLAP00005038863.1, ENSXLAT00005039784.1
    Conserved Domains (2) summary
    cd02126
    Location:650 → 776
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    cl04955
    Location:39 → 484
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQB9.2 GenPept UniProtKB/Swiss-Prot:Q6GQB9

Gene LinkOut

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