rars2.S arginyl-tRNA synthetase 2, mitochondrial S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rars2.S
Official Full Name: arginyl-tRNA synthetase 2, mitochondrial S homeolog
Primary source: Xenbase:XB-GENE-976893
Locus tag: XELAEV_18029394mg
See related: EnsemblRapid:ENSXLAG00005002801 AllianceGenome:Xenbase:XB-GENE-976893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rars2; rarsl
Summary: Predicted to enable arginine-tRNA ligase activity. Predicted to act upstream of or within arginyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (74127708..74158853)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (69455641..69486749)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables arginine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables arginine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within arginyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable arginine--tRNA ligase, mitochondrial

Names: argRS; arginine--tRNA ligase; probable arginyl-tRNA synthetase, mitochondrial

NP_001085437.1

EC 6.1.1.19

XP_018119882.1

EC 6.1.1.19

XP_018119883.1

EC 6.1.1.19

XP_041419931.1

EC 6.1.1.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091968.1 → NP_001085437.1 probable arginine--tRNA ligase, mitochondrial precursor

See identical proteins and their annotated locations for NP_001085437.1

Status: PROVISIONAL

Source sequence(s)

BC072745

UniProtKB/Swiss-Prot

Q6GQJ7

UniProtKB/TrEMBL

A0A974HHK3

Related

ENSXLAP00005008391.1, ENSXLAT00005008517.1

Conserved Domains (3) summary

cd00671
Location:129 → 390

ArgRS_core; catalytic core domain of arginyl-tRNA synthetases

COG0018
Location:63 → 580

ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cl12020
Location:427 → 580

Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

74127708..74158853

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018264394.2 → XP_018119883.1 probable arginine--tRNA ligase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8J0VDM4, A0A974HHK3

Conserved Domains (1) summary

COG0018
Location:15 → 532

ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
XM_018264393.2 → XP_018119882.1 probable arginine--tRNA ligase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8J0VDM4, A0A974HHK3

Conserved Domains (1) summary

COG0018
Location:15 → 532

ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
XM_041563997.1 → XP_041419931.1 probable arginine--tRNA ligase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8J0VDM4, A0A974HHK3

Conserved Domains (1) summary

COG0018
Location:15 → 532

ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]