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gphn.S gephyrin S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443802, updated on 4-Nov-2024

Summary

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Official Symbol
gphn.S
Official Full Name
gephyrin S homeolog
Primary source
Xenbase:XB-GENE-17333130
Locus tag
XELAEV_18042672mg
See related
EnsemblRapid:ENSXLAG00005020657 AllianceGenome:Xenbase:XB-GENE-17333130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable molybdopterin adenylyltransferase activity and molybdopterin molybdotransferase activity. Predicted to act upstream of or within several processes, including molybdenum incorporation into molybdenum-molybdopterin complex; postsynaptic neurotransmitter receptor diffusion trapping; and synapse organization. Predicted to be located in several cellular components, including dendrite; postsynaptic membrane; and postsynaptic specialization. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gphn.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
29
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (92725580..92946544, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (87966437..88115410, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016763994.1 (1..262)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene MAGUK p55 subfamily member 5 Neighboring gene ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D S homeolog Neighboring gene fucosyltransferase 8 (alpha (1,6) fucosyltransferase) S homeolog Neighboring gene uncharacterized LOC121397553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC83148

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables molybdopterin adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin molybdotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of synaptic specificity at neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid receptor clustering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycine receptor clustering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within molybdenum incorporation into molybdenum-molybdopterin complex IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within postsynaptic neurotransmitter receptor diffusion trapping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic specialization IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gephyrin S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091907.1 → NP_001085376.1  gephyrin S homeolog

    See identical proteins and their annotated locations for NP_001085376.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071153
    UniProtKB/TrEMBL
    Q6GQZ6
    Related
    ENSXLAP00005060880.1, ENSXLAT00005062332.1
    Conserved Domains (4) summary
    pfam09595
    Location:269 → 419
    Metaviral_G; Metaviral_G glycoprotein
    COG0303
    Location:445 → 854
    MoeA; Molybdopterin biosynthesis enzyme [Coenzyme transport and metabolism]
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:451 → 857
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    92725580..92946544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574186.1 → XP_041430120.1  gephyrin S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LN33
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:535 → 941
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  2. XM_041574188.1 → XP_041430122.1  gephyrin S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LKS7
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:516 → 922
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  3. XM_041574190.1 → XP_041430124.1  gephyrin S homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J1LLW1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:511 → 917
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  4. XM_041574191.1 → XP_041430125.1  gephyrin S homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J1LN38
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:503 → 909
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  5. XM_041574187.1 → XP_041430121.1  gephyrin S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LLK9
    Related
    ENSXLAP00005060803.1, ENSXLAT00005062255.1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:524 → 930
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  6. XM_041574189.1 → XP_041430123.1  gephyrin S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1LKM0
    Related
    ENSXLAP00005060822.1, ENSXLAT00005062275.1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:514 → 920
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  7. XM_041574192.1 → XP_041430126.1  gephyrin S homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J1LLL5
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:502 → 908
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  8. XM_041574193.1 → XP_041430127.1  gephyrin S homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J1LKT1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:500 → 906
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  9. XM_041574203.1 → XP_041430137.1  gephyrin S homeolog isoform X17

    UniProtKB/TrEMBL
    A0A8J1LKU1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:425 → 831
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  10. XM_041574194.1 → XP_041430128.1  gephyrin S homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J1LKM5
    Related
    ENSXLAP00005060863.1, ENSXLAT00005062315.1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:483 → 889
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  11. XM_041574195.1 → XP_041430129.1  gephyrin S homeolog isoform X10

    UniProtKB/TrEMBL
    A0A8J1LLW6
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:479 → 885
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  12. XM_041574204.1 → XP_041430138.1  gephyrin S homeolog isoform X18

    UniProtKB/TrEMBL
    A0A8J1LKN6
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:416 → 822
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  13. XM_041574198.1 → XP_041430132.1  gephyrin S homeolog isoform X12

    UniProtKB/TrEMBL
    A0A8J1LKT6
    Related
    ENSXLAP00005060886.1, ENSXLAT00005062338.1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:469 → 875
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  14. XM_041574197.1 → XP_041430131.1  gephyrin S homeolog isoform X11

    UniProtKB/TrEMBL
    A0A8J1LLM0
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:472 → 878
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  15. XM_041574199.1 → XP_041430133.1  gephyrin S homeolog isoform X13

    UniProtKB/TrEMBL
    A0A8J1LKN0
    Conserved Domains (3) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:462 → 868
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    pfam05109
    Location:281 → 455
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  16. XM_041574205.1 → XP_041430139.1  gephyrin S homeolog isoform X19

    UniProtKB/TrEMBL
    A0A8J1LLX5
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:395 → 801
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  17. XM_041574200.1 → XP_041430134.1  gephyrin S homeolog isoform X14

    UniProtKB/TrEMBL
    A0A8J1LLX0
    Related
    ENSXLAP00005060898.1, ENSXLAT00005062349.1
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:458 → 864
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  18. XM_041574201.1 → XP_041430135.1  gephyrin S homeolog isoform X15

    UniProtKB/TrEMBL
    A0A8J1LN51
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:448 → 854
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  19. XM_041574202.1 → XP_041430136.1  gephyrin S homeolog isoform X16

    UniProtKB/TrEMBL
    A0A8J1LLM6
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:437 → 843
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  20. XM_041574206.1 → XP_041430140.1  gephyrin S homeolog isoform X20

    UniProtKB/TrEMBL
    A0A8J1LN56
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:373 → 779
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  21. XM_041574208.1 → XP_041430142.1  gephyrin S homeolog isoform X21

    UniProtKB/TrEMBL
    A0A8J1LKU6
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:360 → 766
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  22. XM_041574209.1 → XP_041430143.1  gephyrin S homeolog isoform X22

    UniProtKB/TrEMBL
    A0A8J1LKP2
    Conserved Domains (2) summary
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:327 → 733
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
Nucleotide Protein Strain
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