spopl.L speckle type POZ protein like L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: spopl.L
Official Full Name: speckle type POZ protein like L homeolog
Primary source: Xenbase:XB-GENE-5871534
Locus tag: XELAEV_18044539mg
See related: EnsemblRapid:ENSXLAG00005025126 AllianceGenome:Xenbase:XB-GENE-5871534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: spopl; spopl.S
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to act upstream of or within negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9_10L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (64228556..64253100)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (53702400..53725180)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: speckle-type POZ protein-like

Names: speckle type POZ protein like S homeolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091889.1 → NP_001085358.1 speckle-type POZ protein-like

See identical proteins and their annotated locations for NP_001085358.1

Status: PROVISIONAL

Source sequence(s)

BC071125

UniProtKB/Swiss-Prot

Q6GR09

UniProtKB/TrEMBL

A0A974BYY5

Related

ENSXLAP00005074596.1, ENSXLAT00005076176.1

Conserved Domains (4) summary

smart00225
Location:201 → 297

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:297 → 377

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:193 → 294

BTB; BTB/POZ domain

cl02446
Location:28 → 166

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...