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ppm1b.L protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443768, updated on 4-Nov-2024

Summary

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Official Symbol
ppm1b.L
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog
Primary source
Xenbase:XB-GENE-999176
Locus tag
XELAEV_18026156mg
See related
EnsemblRapid:ENSXLAG00005010041 AllianceGenome:Xenbase:XB-GENE-999176
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pp2cb; ppm1b; ppm1b.S; pp2cbeta; ppc2betax; pp2c-beta-x
Summary
Predicted to enable magnesium ion binding activity; manganese ion binding activity; and myosin phosphatase activity. Predicted to act upstream of or within peptidyl-threonine dephosphorylation; positive regulation of canonical Wnt signaling pathway; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol; membrane; and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ppm1b.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (7948510..7980506, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (7222947..7255992, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene prolyl endopeptidase-like L homeolog Neighboring gene solute carrier family 3 (amino acid transporter heavy chain), member 1 L homeolog Neighboring gene uncharacterized LOC121393515 Neighboring gene leucine rich pentatricopeptide repeat containing L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81273

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-threonine dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog
Names
protein phosphatase, Mg2+/Mn2+ dependent 1B S homeolog
protein phosphatase, Mg2+/Mn2+ dependent, 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091873.1 → NP_001085342.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog

    See identical proteins and their annotated locations for NP_001085342.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071108
    UniProtKB/TrEMBL
    Q6GR26
    Related
    ENSXLAP00005029596.1, ENSXLAT00005030340.1
    Conserved Domains (2) summary
    cd00143
    Location:22 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    7948510..7980506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041562184.1 → XP_041418118.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1KN12
    Related
    ENSXLAP00005029575.1, ENSXLAT00005030321.1
    Conserved Domains (1) summary
    cd00143
    Location:22 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. XM_018261859.2 → XP_018117348.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A1L8G6L5, A0A974CTD1
    Related
    ENSXLAP00005029614.1, ENSXLAT00005030361.1

  3. XM_018261857.2 → XP_018117346.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0V890

  4. XM_018261858.2 → XP_018117347.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0V890

  5. XM_018261856.2 → XP_018117345.1  protein phosphatase, Mg2+/Mn2+ dependent 1B L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0V890
    Related
    ENSXLAP00005029584.1, ENSXLAT00005030330.1
Nucleotide Protein Strain
Heading Accession and Version

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