U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mdh2.S malate dehydrogenase 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443751, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mdh2.S
Official Full Name
malate dehydrogenase 2 S homeolog
Primary source
Xenbase:XB-GENE-971719
Locus tag
XELAEV_18015312mg
See related
EnsemblRapid:ENSXLAG00005002897 AllianceGenome:Xenbase:XB-GENE-971719
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mdh2; mor1; Mdh2b; m-mdh; mdh2-a; mdh2-b
Summary
Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to act upstream of or within malate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mdh2.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (85765118..85781003)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (77200773..77216714)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene Z30 small nucleolar RNA Neighboring gene rhomboid domain containing 2 S homeolog Neighboring gene P450 (cytochrome) oxidoreductase S homeolog Neighboring gene serine/arginine repetitive matrix 3 S homeolog Neighboring gene scavenger receptor cysteine rich family, 4 domains S homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Localization, structure and polymorphism of two paralogous Xenopus laevis mitochondrial malate dehydrogenase genes. Tlapakova T, et al. Chromosome Res, 2005. PMID 16235119
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC79037

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables L-malate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
malate dehydrogenase 2 S homeolog
Names
malate dehydrogenase 2, NAD (mitochondrial)
mitochondrial malate dehydrogenase 2b
NP_001085326.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091857.1 → NP_001085326.1  malate dehydrogenase 2 S homeolog

    See identical proteins and their annotated locations for NP_001085326.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071073
    UniProtKB/TrEMBL
    A0A974DIB8, Q6GR58
    Related
    ENSXLAP00005008710.1, ENSXLAT00005008836.1
    Conserved Domains (2) summary
    cd01337
    Location:26 → 334
    MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
    PLN00106
    Location:8 → 329
    PLN00106; malate dehydrogenase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    85765118..85781003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.