rnaseh2a.L ribonuclease H2 subunit A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rnaseh2a.L
Official Full Name: ribonuclease H2 subunit A L homeolog
Primary source: Xenbase:XB-GENE-945846
Locus tag: XELAEV_18019079mg
See related: EnsemblRapid:ENSXLAG00005002722 AllianceGenome:Xenbase:XB-GENE-945846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rnaseh2a
Summary: Predicted to enable RNA binding activity; RNA-DNA hybrid ribonuclease activity; and metal ion binding activity. Predicted to act upstream of or within DNA replication, removal of RNA primer and mismatch repair. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (149800000..149822749, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (132896270..132919187, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication, removal of RNA primer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ribonuclease H2 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease H2 subunit A L homeolog

Names: ribonuclease H2, subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193406.1 → NP_001180335.1 ribonuclease H2 subunit A L homeolog

See identical proteins and their annotated locations for NP_001180335.1

Status: PROVISIONAL

Source sequence(s)

BC099334

UniProtKB/TrEMBL

Q4FZN2, Q6GNJ4

Related

ENSXLAP00005008080.1, ENSXLAT00005008204.1

Conserved Domains (1) summary

cd07181
Location:31 → 250

RNase_HII_eukaryota_like; Eukaryotic RNase HII

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

149800000..149822749 complement

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GenBank, FASTA, Sequence Viewer (Graphics)